Effect of Preoperative Oral Antibiotics on Surgical Site Infections in Colorectal Surgery
Author Information
Author(s): Nakanishi Ryo, Ozawa Heita, Toyota Naoyuki, Mise Minori, Fujita Shin
Primary Institution: Tochigi Cancer Center
Hypothesis
Can preoperative oral antibiotics reduce the incidence of incisional surgical site infections in colorectal surgery?
Conclusion
Preoperative oral antibiotics significantly reduce the rate of incisional surgical site infections in colorectal surgery.
Supporting Evidence
- Patients receiving oral antibiotics had a significantly lower rate of incisional surgical site infections compared to those who did not.
- The odds ratio for infection was 3.4 times higher in the non-antibiotic group.
- Preoperative oral antibiotics were administered in a divided dose starting the day before surgery.
Takeaway
Giving patients antibiotics before colorectal surgery helps prevent infections in their wounds.
Methodology
This study used a retrospective observational design with propensity score matching to compare outcomes between patients receiving oral antibiotics and those who did not.
Potential Biases
Potential bias due to the involvement of multiple surgeons and changes in surgical techniques over time.
Limitations
The study is limited by its single-center design and retrospective nature, which may introduce bias.
Participant Demographics
{"median_age":70,"sex_distribution":{"male":60,"female":40},"median_BMI":22.7}
Statistical Information
P-Value
0.0062
Confidence Interval
95% CI: 0.123–0.707
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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