Splenic rupture, secondary to G-CSF use for chemotherapy induced neutropenia: a case report and review of literature
2008
Splenic Rupture from G-CSF Use in Chemotherapy
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Masood Nehal, Shaikh Asim Jamal, Memon Wasim Ahmed, Idress Romana
Primary Institution: Aga Khan University Hospital, Karachi, Pakistan
Hypothesis
Can G-CSF therapy lead to splenic rupture in patients undergoing chemotherapy?
Conclusion
Splenic rupture, although extremely rare, can occur as a serious complication of high-dose G-CSF therapy.
Supporting Evidence
- G-CSF is commonly used to treat neutropenia caused by chemotherapy.
- Splenic rupture is a rare but serious side effect of high-dose G-CSF therapy.
- The patient required splenectomy after experiencing severe pain and a CT scan indicating splenic rupture.
Takeaway
A young man receiving G-CSF for chemotherapy got a splenic rupture, which is a very rare but serious side effect.
Methodology
Case report of a 20-year-old man treated for T-cell acute lymphoblastic leukemia who experienced splenic rupture after G-CSF therapy.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
One 20-year-old male patient.
Digital Object Identifier (DOI)
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