HPV and Cervical Cancer in Brazil
Author Information
Author(s): J. Eluf-Netol, M. Booth, N. Mufnoz, F.X. Bosch, C.J.L.M. Meijer, J.M.M. Walboomers
Primary Institution: Faculdade de Medicina, Universidade de Sao Paulo
Hypothesis
What is the role of human papillomavirus (HPV) in the development of invasive cervical cancer in Brazil?
Conclusion
The study found that HPV DNA was present in 84% of cervical cancer cases, indicating a strong association between HPV and cervical cancer.
Supporting Evidence
- HPV DNA was detected in 84% of the cases compared to 17% of controls.
- 66% of cases were positive for high-risk HPV types 16, 18, 31, and 33.
- The odds ratio for cervical cancer associated with HPV 16, 18, 31, and 33 was 69.7.
- Number of sexual partners and early age at first intercourse were significantly associated with increased risk.
- A history of previous Papanicolaou smears was significantly associated with decreased risk.
Takeaway
This study shows that a lot of women with cervical cancer have a virus called HPV, which can cause the disease.
Methodology
A hospital-based case-control study with 199 cervical cancer cases and 225 matched controls, using PCR to detect HPV DNA.
Potential Biases
Potential misclassification of HPV status and selection bias due to hospital-based design.
Limitations
The study was hospital-based and not restricted to women with permanent residence in Sao Paulo.
Participant Demographics
Women aged 25 to 79 years, with a mean age of 52.1 years for cases and 52.4 years for controls.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 28.7-169.6
Statistical Significance
p<0.001
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