Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus
2001
Study of the ANA Gene in Oral Cancer
Sample size: 63
publication
Evidence: moderate
Author Information
Author(s): Yamamoto N, Uzawa K, Yakushiji T, Shibahara T, Noma H, Tanzawa H
Primary Institution: Tokyo Dental College
Hypothesis
The study investigates the role of the ANA gene and loss of heterozygosity on chromosome 21 in oral cancer susceptibility.
Conclusion
The loss of ANA gene expression may contribute to the progression of oral squamous cell carcinoma.
Supporting Evidence
- 50.8% of the examined oral squamous cell carcinomas showed loss of heterozygosity at chromosome 21q.
- 60% of tumors showed absent or reduced mRNA expression of the ANA gene.
- 88.9% of OSCC-derived cell lines had reduced ANA gene expression.
- Re-expression of the ANA gene was induced in cell lines after treatment with a DNA demethylating agent.
Takeaway
Researchers looked at a gene called ANA to see if it plays a role in oral cancer, and they found that many tumors had less of this gene, especially in advanced cases.
Methodology
The study examined 63 oral squamous cell carcinomas for loss of heterozygosity at chromosome 21q using microsatellite markers.
Digital Object Identifier (DOI)
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