Microbial Metabolite Receptors in Cancer
Author Information
Author(s): Dovrolis Nikolas, Spathakis Michail, Collins Alexandra R., Pandey Varun Kumar, Uddin Muhammad Ikhtear, Anderson Donald D., Kaminska Tetiana, Paspaliaris Vasilis, Kolios George, Yoshiyama Hironori, Marotta Francesco
Primary Institution: Democritus University of Thrace
Hypothesis
This study investigates the involvement of microbial metabolite receptors (MMRs) in human cells across twenty-three types of cancer.
Conclusion
The interactions between microbial metabolites and MMRs may serve as potential biomarkers for cancer diagnosis, prognosis, and therapy.
Supporting Evidence
- Certain MMRs are consistently upregulated in various malignancies.
- Identified significant correlations between MMR expression and cancer hallmark genes and pathways.
- Microbial metabolites can influence cancer development and progression.
Takeaway
Bacteria in our gut can affect cancer by producing substances that interact with our cells, and this study looks at how these interactions happen in different types of cancer.
Methodology
The study analyzed transcriptomic profiles of 107 MMRs across 23 cancer types using data from cancer cell lines and human tumor samples.
Potential Biases
The reliance on existing datasets may introduce biases related to data quality and representativeness.
Limitations
The study is based entirely on in silico analyses without experimental validation.
Participant Demographics
The study analyzed data from approximately 8500 tumor samples and 740 matched controls across various cancer types.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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