Evaluation of Antihypercholesteremic Activity of Indigenous Plants
Author Information
Author(s): Vithlani D, Sharma V, Sathaye SS
Primary Institution: University Institute of Chemical Technology, Mumbai, India
Hypothesis
The study aims to evaluate the antihypercholesteremic activity of methanolic extracts of Trigonella foenumm, Trachyspermum copticum, and Nigella sativa in male Sprague-Dawley rats.
Conclusion
The combination of methanolic extracts of the three plants showed better antihypercholesteremic activity than individual extracts.
Supporting Evidence
- The combination of extracts showed a dose-dependent effect.
- All extracts significantly increased fecal cholesterol excretion.
- Atorvastatin calcium was used as a control and showed significant effects.
Takeaway
This study tested some plants to see if they can help lower cholesterol in rats, and found that using a mix of them worked better than using just one.
Methodology
Male Sprague-Dawley rats were given cholesterol and cholic acid for 6 weeks, followed by treatment with plant extracts for 14 days, with blood samples taken to measure cholesterol levels.
Participant Demographics
Male Sprague-Dawley rats
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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