HIT family genes: FHIT but not PKCI-1/HINT produces altered transcripts in colorectal cancer
1999
HIT Family Genes and Colorectal Cancer
Sample size: 45
publication
Evidence: moderate
Author Information
Author(s): Elnatan J, Murphy D, Goh H-S, Smith D R
Primary Institution: Molecular Biology Laboratory, Tan Tock Seng Hospital
Hypothesis
Are FHIT and PKCI-1/HINT genes altered in colorectal cancer?
Conclusion
The study found that alterations in FHIT gene expression are an early event in colorectal tumorigenesis.
Supporting Evidence
- 45 colorectal adenocarcinomas were examined for alterations in the HIT family genes.
- Multiple transcripts were detected for the FHIT gene, while a single transcript was found for PKCI-1/HINT.
- 3 out of 45 tumors showed no detectable expression of FHIT transcripts.
Takeaway
The study looked at 45 colorectal cancer samples and found changes in a specific gene that might help us understand how this cancer develops.
Methodology
The researchers examined colorectal adenocarcinomas for gene alterations using reverse transcriptase polymerase chain reaction and DNA sequencing.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website