Screening for ATM Mutations in Breast Cancer Patients
Author Information
Author(s): Laake K, Vu P, Andersen T I, Erikstein B, Kåresen R, Lønning P E, Skovlund E, Børresen-Dale A L
Primary Institution: The Norwegian Radium Hospital
Hypothesis
Is there an increased risk of breast cancer associated with ATM mutations in Norwegian patients?
Conclusion
The study found no evidence of an increased risk of breast cancer linked to ATM mutations in the screened population.
Supporting Evidence
- 483 Norwegian breast cancer patients were screened for six different ATM mutations.
- Only one carrier of the mutation was found.
- The results suggest no excess risk of breast cancer associated with ATM mutations.
Takeaway
The researchers looked at breast cancer patients to see if a specific gene mutation made them more likely to get breast cancer, but they found that it didn't.
Methodology
Screening for six different ATM mutations using polymerase chain reaction.
Limitations
Only one carrier of the mutation was found, which limits the ability to draw broader conclusions.
Participant Demographics
Norwegian breast cancer patients.
Statistical Information
Confidence Interval
maximum 2.4-fold increased risk
Digital Object Identifier (DOI)
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