A Reconsideration of the Link between the Energetics of Water and of ATP Hydrolysis Energy in the Power Strokes of Molecular Motors in Protein Structures
2008

Reconsidering the Energetics of Water and ATP in Muscle Contraction

publication 10 minutes Evidence: moderate

Author Information

Author(s): Widdas Wilfred F.

Primary Institution: Faculty of Science, University of London, UK

Hypothesis

The study proposes that both the surface energy of water and ATP hydrolysis contribute to mechanical work in muscle contractions.

Conclusion

The surface energy of water may play a significant role in muscle contractions, potentially more than previously understood.

Supporting Evidence

  • Mechanical energy from oxygen metabolism has been studied since 1837.
  • The surface energy of water can do mechanical work in biological systems.
  • Electrostatic forces are considered important for muscle and molecular science.

Takeaway

This study suggests that water can help muscles move, not just the energy from food. It's like using a balloon to push something instead of just your hands.

Methodology

The study reviews historical and experimental evidence regarding the roles of ATP hydrolysis and water's surface energy in muscle contractions.

Limitations

The study primarily focuses on theoretical models and may not account for all biochemical complexities in muscle physiology.

Digital Object Identifier (DOI)

10.3390/ijms9091730

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