C17 Prevents Inflammatory Arthritis in Mice
Author Information
Author(s): Chao Connie, Joyce-Shaikh Barbara, Grein Jeff, Moshrefi Mehrdad, Raoufi Fahimeh, Laface Drake M., McClanahan Terril K., Bourne Patricia A., Pierce Robert H., Gorman Daniel M., Pflanz Stefan
Primary Institution: Merck Research Labs, Palo Alto, California, United States of America
Hypothesis
C17 is a cytokine possessing immune-regulatory properties.
Conclusion
C17 reduces disease severity and joint damage in a mouse model of inflammatory arthritis.
Supporting Evidence
- C17 reduces disease incidence and clinical scores in a mouse model of arthritis.
- C17-treated mice showed minimal swelling compared to controls.
- Histological analysis revealed less joint damage in C17-treated mice.
Takeaway
C17 helps protect mice from arthritis by reducing swelling and joint damage.
Methodology
Mice were injected with C17 minicircle DNA and then induced with arthritis to assess disease progression.
Limitations
C17 did not show therapeutic effects once arthritis was established.
Participant Demographics
Male B10.RIII mice, aged 12-16 weeks.
Statistical Information
P-Value
0.007
Statistical Significance
p=0.007
Digital Object Identifier (DOI)
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