Risk of Invasive Breast Cancer After In Situ Carcinoma
Author Information
Author(s): Rawal R, Bermejo J Lorenzo, Hemminki K
Primary Institution: German Cancer Research Center
Hypothesis
What is the risk of developing invasive breast cancer after being diagnosed with in situ breast carcinoma?
Conclusion
Women with in situ breast cancer have a significantly increased risk of developing invasive breast cancer, especially if diagnosed before age 50.
Supporting Evidence
- Women with in situ breast cancer showed a relative risk of 2.03 for contralateral and 3.94 for ipsilateral invasive breast cancer.
- The risk was higher for in situ carcinomas diagnosed before the age of 50 years.
- The incidence of invasive ductal cancer increased from 46.8 to 66.1/100,000 between 1993 and 2000.
Takeaway
If a woman has a type of breast cancer that hasn't spread, she is more likely to get a more serious type of breast cancer later on, especially if she is younger.
Methodology
The study used the Swedish Family-Cancer Database to analyze the risk of invasive breast cancer following in situ carcinoma, employing Poisson regression analysis.
Potential Biases
The study may be affected by treatment and follow-up differences that complicate the epidemiology of second breast cancers.
Limitations
Information on confounders such as treatment received and tumor size was not available.
Participant Demographics
The study included a population of five million women in Sweden.
Statistical Information
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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