Impact of Prehabilitation with High Protein Supplementation on Sarcopenic Surgical Patients
Author Information
Author(s): Koh Frederick Hong-Xiang, Yik Vanessa, Chin Shuen-Ern, Kok Shawn Shi-Xian, Lee Hui-Bing, Tong Cherie, Tay Phoebe, Chean Esther, Lam Yi-En, Mah Shi-Min, Foo Li-Xin, Yan Clement C, Chua Wei-Tian, Jamil Haziq bin, G Khasthuri, Ong Lester Wei-Lin, Tan Alvin Yong-Hui, Chue Koy-Min, Ho Leonard Ming-Li, Chong Cheryl Xi-Zi, Ladlad Jasmine, Tan Cheryl Hui-Min, Khoo Nathanelle Ann Xiaolian, Ng Jia-Lin, Tan Winson Jianhong, Foo Fung-Joon
Primary Institution: Sengkang General Hospital, Singapore
Hypothesis
This study aims to explore the impact of a multimodal prehabilitation program using high-protein oral nutritional supplementation with HMB and resistance exercise on muscle quality and functional outcomes in sarcopenic surgical patients.
Conclusion
The increase in the IMAT index in sarcopenic surgical patients undergoing prehabilitation may be due to altered muscle metabolism in elderly patients.
Supporting Evidence
- 36 sarcopenic patients were included in the study.
- IMAT index increased significantly after two weeks of prehabilitation.
- Improvement in gait speed was observed after two weeks of prehabilitation.
- Median length of hospital stay was 7 days.
- Compliance to HP ONS with HMB was 83%.
Takeaway
This study shows that giving special nutrition and exercise to older patients before surgery can help their muscles get better and improve how they move.
Methodology
A prospective non-randomized interventional pilot cohort study was performed with sarcopenic adult patients undergoing elective major gastrointestinal surgeries, involving a 2–4-week multimodal prehabilitation program.
Potential Biases
The study lacks a control group for comparison.
Limitations
The study is a proof-of-concept one-arm pilot trial with a small sample size and short follow-up duration.
Participant Demographics
Median age of participants was 71.5 years, with 50% male and 66.7% having severe sarcopenia.
Statistical Information
P-Value
p = 0.032 for IMAT index increase after two weeks of prehabilitation
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website