HPV Genotypes in Invasive Cervical Cancer in Western China
Author Information
Author(s): Kou Yuling, Tang Xiao, Liang Dongni, Xie Chuan, Zeng Jing, Chen Meng, Fu Wenjing, Li Zhonghua, He Qingfeng, Liu Tianming, Wang Mei, Wang Wei, Wang Cheng
Primary Institution: West China Second University Hospital, Sichuan University
Hypothesis
Understanding the HPV genotype distribution in invasive cervical cancer (ICC) is essential for vaccine optimization.
Conclusion
The study suggests that incorporating the bivalent vaccine into the national program is cost-effective and can guide future prevention strategies.
Supporting Evidence
- The overall prevalence of HPV infection was 94.9% among 1,908 women with ICC.
- HPV genotypes 16 and 18 were detected in 90.9% of HPV-positive patients.
- HPV genotypes contained in the 9-valent vaccine were detected in 98.1% of patients.
- The cumulative attribution rates of the bivalent vaccine was 83.4%.
- The cumulative attribution rates of the nine-valent vaccine was 89.8%.
Takeaway
This study looked at how common different types of HPV are in women with cervical cancer in western China, which can help improve vaccines.
Methodology
DNA was extracted from 1,908 paraffin-embedded ICC samples, and 23 HPV genotypes were detected via PCR and reverse dot hybridization gene chip assays.
Potential Biases
The study may be influenced by the COVID-19 outbreak and policies during data collection.
Limitations
Selection bias may be present due to the retrospective nature of the study and the small sample size of patients with rare carcinomas.
Participant Demographics
The study included 1,908 female patients with ICC from 12 provinces in western China.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 93.8–95.8
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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