ADAM33 and Psoriasis Susceptibility
Author Information
Author(s): Lesueur Fabienne, Oudot Tiphaine, Heath Simon, Foglio Mario, Lathrop Mark, Prud'homme Jean-François, Fischer Judith
Primary Institution: Centre National de Génotypage, Evry, France
Hypothesis
Is the ADAM33 gene associated with susceptibility to psoriasis?
Conclusion
The study identifies ADAM33 as a significant gene associated with psoriasis susceptibility in French families.
Supporting Evidence
- ADAM33 was found to be significantly associated with psoriasis in a family set.
- The best association was on a 3-SNP haplotype with a p-value of 0.00004.
- Previous studies linked ADAM33 to asthma, suggesting common genetic pathways for immune diseases.
Takeaway
Scientists found a gene called ADAM33 that might make some people more likely to get psoriasis, a skin disease.
Methodology
The study used a family-based association test (FBAT) to analyze SNP markers in a candidate region linked to psoriasis.
Limitations
The association could not be replicated in a smaller set of families, indicating potential genetic heterogeneity.
Participant Demographics
The study involved 295 nuclear families from France, primarily of Caucasian descent.
Statistical Information
P-Value
0.00004
Statistical Significance
p<0.00005
Digital Object Identifier (DOI)
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