Heart Changes in Diabetic Kidney Disease
Author Information
Author(s): Chen Szu-Chia, Chang Jer-Ming, Liu Wan-Chun, Tsai Yi-Chun, Tsai Jer-Chia, Su Ho-Ming, Hwang Shang-Jyh, Chen Hung-Chun
Primary Institution: Kaohsiung Medical University Hospital
Hypothesis
This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at various stages of chronic kidney disease (CKD).
Conclusion
Increases in LVMI and decreases in LVEF coincide with advances in CKD stages in patients with diabetes.
Supporting Evidence
- The prevalence of left ventricular hypertrophy (LVH) was 62.5% in the study population.
- A significant stepwise increase in LVMI was observed with advancing CKD stages.
- The prevalence of LVEF < 55% was 10.5%, indicating left ventricular systolic dysfunction.
Takeaway
As kidney disease gets worse in diabetes patients, their heart's size increases and its pumping ability decreases.
Methodology
This cross-sectional study enrolled 285 diabetic patients with CKD stages 3 to 5 and compared clinical and echocardiographic parameters.
Limitations
The study had a cross-sectional design, limiting the ability to evaluate predictors of cardiovascular events.
Participant Demographics
The study included 285 nondialyzed CKD patients (174 men and 111 women, mean age 66.4 ± 11.6 years).
Statistical Information
P-Value
P < 0.001 for LVMI trend, P = 0.038 for LVEF trend
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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