Antimicrobial and Toxicological Evaluation of Baissea axillaries Leaves for HIV/AIDS Management
Author Information
Author(s): Abere Tavs A, Agoreyo Freddy O
Primary Institution: University of Benin, Benin-City, Nigeria
Hypothesis
The leaves of Baissea axillaries have antimicrobial activity and a manageable toxicological profile for use in HIV/AIDS patients.
Conclusion
Baissea axillaries extracts show antimicrobial activity against certain microorganisms and potential for treating diarrhea associated with HIV/AIDS, though toxicity is observed at higher doses.
Supporting Evidence
- Phytochemical studies revealed the presence of alkaloids, tannins, and cyanogenetic glycosides.
- The extracts inhibited the growth of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.
- The LD50 of the extract in mice was above 5000 mg/kg body weight.
- Toxicological evaluation showed ballooning degeneration of the liver at 250 mg/kg and tissue necrosis at 500 mg/kg.
Takeaway
This study looks at a plant that might help people with HIV/AIDS by fighting infections, but it can be harmful in large amounts.
Methodology
The study used chemical tests, chromatographic methods, and toxicity evaluations on Wistar rats to assess the antimicrobial and toxicological properties of Baissea axillaries extracts.
Limitations
Further studies are needed to fully establish the safety profile and mechanism of action of Baissea axillaries.
Participant Demographics
Male Wistar rats were used for the toxicity evaluation.
Digital Object Identifier (DOI)
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