Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3
1999
TIMP-3's Role in Cancer Cell Invasion and Apoptosis
publication
Evidence: moderate
Author Information
Author(s): Baker A H, George S J, Zaltsman A B, Murphy G, Newby A C
Primary Institution: Division of Surgery, University of Bristol
Hypothesis
Can TIMP-3 inhibit invasion and promote apoptosis in various cancer cell types?
Conclusion
TIMP-3 inhibits cancer cell invasion and promotes apoptosis in different cancer cell types.
Supporting Evidence
- TIMP-3 inhibits invasion of HeLa and HT1080 cells.
- TIMP-3 promotes apoptosis confirmed by various methods.
- The apoptotic effect can be mimicked by adding recombinant TIMP-3.
Takeaway
TIMP-3 helps stop cancer cells from spreading and can make them die, which is important for treating cancer.
Methodology
Adenoviral-mediated overexpression of TIMP-3 was used to test its effects on cancer cell invasion and apoptosis.
Digital Object Identifier (DOI)
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