Assessing the Generalizability of People Living with HIV in the All of Us Database
Author Information
Author(s): Plummer Narcissa, Ratnayake Aneeka, Olivieri-Mui Brianne, Cavanaugh Robert
Primary Institution: Northeastern University
Hypothesis
This study aimed to establish the generalizability of data self-reported by people living with HIV in the All of Us program to CDC HIV surveillance statistics.
Conclusion
The All of Us program has successfully oversampled older ages, but self-reported people living with HIV are Whiter than expected, limiting generalizability to the US HIV population.
Supporting Evidence
- Of the 409,420 All of Us participants, 1,714 people self-reported having HIV.
- The largest race/ethnicity group among participants was non-Hispanic White (45.7%).
- Compared to national surveillance data, the All of Us program was similar in gender but different in age and race/ethnicity.
Takeaway
This study looked at how well the information from people living with HIV in a big research program matches what we know about all people with HIV in the US.
Methodology
A cross-sectional descriptive analysis comparing demographic statistics of All of Us participants who self-reported as living with HIV to CDC HIV surveillance statistics using Pearson’s chi-squared tests.
Limitations
Interpretations of the All of Us data are limited in generalizability to the US HIV population due to the racial composition of self-reported participants.
Participant Demographics
Most participants were male (76.4%), with a non-heterosexual sexual orientation (71.2%), and nearly half were 55 and older.
Statistical Information
P-Value
0.103
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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