VKORC1 Polymorphism and Anticoagulant Dose in North India
Author Information
Author(s): Rathore S. S., Agarwal S. K., Pande S., Mittal T., Mittal B.
Primary Institution: Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Hypothesis
The study aimed to determine the relationship between the VKORC1-1639 G>A genotypes and maintenance doses of oral anticoagulants for therapeutically stable INR values in patients taking Acitrom after valve replacement surgery.
Conclusion
The VKORC1-1639 G>A status can be indicative of establishing the therapeutic dose of oral anticoagulants in Indian patients.
Supporting Evidence
- The VKORC1 1639G>A minor allele frequency in the study population was found to be 22%.
- Patients with a wild type genotype required the maximum drug dose.
- Heterozygous patients had an intermediate drug dose requirement.
- Variant homozygous genotype patients had the minimum maintenance drug dose requirement.
Takeaway
This study found that different genetic types affect how much anticoagulant medicine people need after heart surgery.
Methodology
Fifty patients were genotyped for VKORC1-1639 G>A by polymerase chain reaction and restriction fragment length polymorphism.
Limitations
The study was carried out in a relatively smaller number of patients and needs replication in a larger sample size.
Participant Demographics
Patients were from the northern Indian region, aged 18 and above, and had undergone heart valve replacement surgery.
Statistical Information
P-Value
<0.05
Confidence Interval
95% CI: 15.00–31.07
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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