IL-6 Gene Polymorphism and Lipoprotein(a) Levels
Author Information
Author(s): Berthold Heiner K., Laudes Matthias, Krone Wilhelm, Gouni-Berthold Ioanna
Primary Institution: Charité University Medicine Berlin
Hypothesis
Is the IL-6 single nucleotide polymorphism −174G/C associated with baseline serum Lp(a) concentrations?
Conclusion
The IL-6 single nucleotide polymorphism −174G/C is associated with increased odds of having elevated Lp(a).
Supporting Evidence
- The study found that the GC and CC genotypes were associated with significantly increased odds of having elevated Lp(a) concentrations.
- The odds ratio for the GC genotype was 1.3 and for the CC genotype was 1.44.
- These associations remained significant after adjusting for various covariates.
Takeaway
Some people have a gene that makes their Lp(a) levels higher, which can be bad for their heart. This study looked at how that gene affects Lp(a) levels.
Methodology
The study analyzed data from 2321 subjects, measuring Lp(a) levels and genotyping for the −174G/C SNP.
Potential Biases
Potential bias due to the retrospective nature of the study and the specific cohort used.
Limitations
The study is retrospective and does not include new experiments on subjects.
Participant Demographics
The cohort included 2321 subjects with varying Lp(a) levels, with no significant differences in sex distribution, age, or smoking behavior.
Statistical Information
P-Value
0.02 for GC and 0.018 for CC genotypes
Confidence Interval
95% CI 1.04 to 1.63 for GC and 95% CI 1.06 to 1.93 for CC
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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