FROM GEROSCIENCE TO GEROTHERAPEUTICS: KUAKINI CENTER OF RESEARCH EXCELLENCE FOR TRANSLATIONAL RESEARCH ON AGING
2024
Research on Aging and Healthspan Improvement
Sample size: 8006
publication
Evidence: moderate
Author Information
Author(s): Willcox Bradley, Nakagawa Kazuma, Lee Yeonjung, Masaki Kamal, Allsopp Richard
Primary Institution: Kuakini Medical Center
Hypothesis
Can geroscientific principles be utilized to improve human healthspan and develop therapeutic innovations?
Conclusion
The research has identified specific pathways for targeted gerotherapeutic interventions that may contribute to healthier aging.
Supporting Evidence
- The research has collected over 500,000 biological samples and over 900 brains.
- Key findings are consistent with the geroscience hypothesis.
- The study has identified specific pathways for targeted gerotherapeutic interventions.
- Interventions are now in Phase 2 human trials.
Takeaway
This study looks at how we can help people live healthier as they get older by finding new treatments.
Methodology
The study involved comprehensive clinical exams and the collection of biological samples over six decades.
Participant Demographics
American men of Japanese and Okinawan ancestry, aged 45-68 years at baseline.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website