Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement
2024
How ATF6 Helps Octreotide Improve Blood Vessel Barrier
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Saikat Fakir, Nektarios Barabutis, Barbara Ruaro
Primary Institution: University of Louisiana Monroe
Hypothesis
Does activating transcription factor 6 (ATF6) enhance the protective effects of Octreotide (OCT) in endothelial dysfunction?
Conclusion
ATF6 activation prior to OCT treatment enhances the beneficial effects of OCT in the endothelium.
Supporting Evidence
- ATF6 activation significantly improves OCT-induced endothelial barrier enhancement.
- AA147 enhances OCT-induced expression of protective proteins BiP and Grp94.
- ATF6 activation reduces reactive oxygen species generation in endothelial cells.
- Pre-treatment with AA147 leads to better barrier function when combined with OCT.
- ATF6 activation suppresses inflammatory signaling pathways in endothelial cells.
Takeaway
This study shows that a protein called ATF6 can help a medicine called Octreotide work better to protect blood vessels from damage.
Methodology
The study used human and bovine endothelial cells to assess protein expression, permeability, and reactive oxygen species generation after treatment with Octreotide and ATF6 activator AA147.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website