A diagnostic dilemma in breast pathology – benign fibroadenoma with multinucleated stromal giant cells
2008

Benign Breast Tumors with Giant Cells

Sample size: 2 publication Evidence: moderate

Author Information

Author(s): Heneghan Helen M, Martin Sean T, Casey Mary, Tobbia Igdam, Benani Fadel, Barry Kevin M

Primary Institution: Mayo General Hospital, Ireland

Hypothesis

Can multinucleated giant cells in benign fibroadenomas be mistaken for malignant cells?

Conclusion

Multinucleated giant cells in benign fibroadenomas do not indicate malignancy and should be recognized to avoid misdiagnosis.

Supporting Evidence

  • The presence of multinucleated giant cells can lead to misdiagnosis of malignancy.
  • Both cases showed no malignant changes upon histological examination.
  • Correct identification of these cells is crucial for accurate diagnosis.

Takeaway

Sometimes, doctors find unusual giant cells in breast lumps that look scary, but they are actually harmless and don't mean cancer.

Methodology

The study involved case presentations of two patients with benign fibroadenomas containing multinucleated giant cells, including clinical, radiological, and histopathological evaluations.

Limitations

The rarity of multinucleated giant cells in benign breast tumors may lead to diagnostic confusion.

Participant Demographics

Two female patients aged 42 and 48, with no significant personal or family history of breast cancer.

Digital Object Identifier (DOI)

10.1186/1746-1596-3-33

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