Disseminated Intravascular Coagulation in Hemorrhagic Fever with Renal Syndrome
Author Information
Author(s): Erik Sundberg, Johan Hultdin, Sofie Nilsson, Clas Ahlm
Primary Institution: Umeå University, Sweden
Hypothesis
The presence of disseminated intravascular coagulation (DIC) could be used as a prognostic marker for disease severity in patients with hemorrhagic fever with renal syndrome (HFRS).
Conclusion
DIC was found in about one fourth of the patients and correlated with a more severe disease.
Supporting Evidence
- 18.9–28.3% of the patients were diagnosed with DIC.
- DIC-scoring templates modified with a fibrinogen/CRP-ratio were predictive for moderate/severe illness.
- Patients with DIC had significantly higher rates of moderate/severe illness.
Takeaway
This study found that many patients with a specific type of fever had a serious condition called DIC, which can make them sicker.
Methodology
Data from 106 patients with confirmed HFRS were analyzed and scored for the presence of DIC according to six different templates based on ISTH criteria.
Limitations
Many patients were already considered moderate/severe ill at presentation, which may bias the predictive value of the scoring systems.
Participant Demographics
Median age was 53 years, with 54.7% female.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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