Crystallization of an Antibody-Interferon Complex
Author Information
Author(s): Vaheh Oganesyan, Melissa M. Damschroder, Kimberly E. Cook, Herren Wu, William F. Dall’Acqua
Primary Institution: MedImmune
Hypothesis
The study aims to solve the X-ray crystal structure of the complex between a therapeutic antibody fragment and human interferon α-2A.
Conclusion
The first reported crystals of a human type I interferon bound to an antibody were obtained and diffracted to 3.0 Å resolution.
Supporting Evidence
- The crystals diffracted to a resolution of 3.0 Å.
- This is the first report of a human type I interferon bound to an antibody.
- The study provides insights into the mechanism of action of the therapeutic antibody MEDI545.
Takeaway
Scientists made crystals of a special protein that helps fight infections and studied how it works with an antibody. This helps us understand how to use it better in medicine.
Methodology
The Fab fragment of a therapeutic monoclonal antibody was crystallized with human interferon α-2A, and X-ray diffraction data were collected to analyze the structure.
Digital Object Identifier (DOI)
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