Naringenin Protects Kidneys from Dasatinib Damage
Author Information
Author(s): Alhazzani Khalid, Alqarni Naif N., Aljerian Khaldoon, Raish Mohammad, Aljuffali Lobna, Alshehri Samiyah, Alanazi Ahmed Z.
Primary Institution: King Saud University
Hypothesis
Can naringenin mitigate kidney damage caused by dasatinib?
Conclusion
Naringenin effectively reduces kidney damage caused by dasatinib by improving antioxidant levels, reducing inflammation, and modulating apoptosis.
Supporting Evidence
- DASA treatment significantly increased serum levels of kidney damage markers.
- Naringenin pretreatment reduced these markers in a dose-dependent manner.
- Naringenin improved antioxidant levels in kidney tissues.
- Naringenin reduced pro-inflammatory cytokine levels induced by DASA.
- Naringenin modulated the expression of apoptosis-related proteins.
Takeaway
This study shows that naringenin, a natural compound, can help protect the kidneys from damage caused by a cancer drug called dasatinib.
Methodology
Mice were treated with naringenin and dasatinib, followed by analysis of kidney function biomarkers and histopathological examination.
Potential Biases
Potential bias due to the small sample size and lack of detailed mechanistic investigation.
Limitations
The study had a small sample size and used a single dose of dasatinib, which may not reflect chronic exposure effects.
Participant Demographics
Male Swiss albino mice, aged 6-8 weeks, weighing 25-30 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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