Impact of Laparoscopic Nissen Fundoplication on Barrett’s Esophagus
Author Information
Author(s): Mohamed Ashraf A. Mahran, Khaled M. Zaazou, Mohamed M.
Primary Institution: Minia University Hospital, Minia, Egypt
Hypothesis
This study was undertaken to assess the role of laparoscopic fundoplication in patients with non-complicated Barrett’s esophagus.
Conclusion
Laparoscopic fundoplication succeeded in controlling symptoms but had an unpredictable effect on dysplasia and regression of Barrett’s esophagus.
Supporting Evidence
- All patients had gastroesophageal reflux symptoms.
- Heartburn was present in all patients.
- 8 patients with short-segment Barrett’s esophagus had total regression.
- 4 patients with long-segment Barrett’s esophagus had a decrease in total length.
- 7 of 9 patients with low-grade dysplasia had regression to no dysplasia.
Takeaway
Doctors did surgery to help people with a throat problem called Barrett’s esophagus, and it helped most of them feel better, but it didn't always fix the problem completely.
Methodology
43 patients with Barrett’s esophagus underwent laparoscopic Nissen fundoplication, and their symptoms were evaluated before and after surgery over a median follow-up of 25.6 months.
Limitations
The study does not predict which patients will experience regression of Barrett’s esophagus or dysplasia.
Participant Demographics
32 men and 11 women, median age 46 years (range: 22–68 years).
Statistical Information
P-Value
p=0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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