Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study
2001

Vitamins and Bladder Cancer Risk

Sample size: 120852 publication Evidence: moderate

Author Information

Author(s): Zeegers M P A, Goldbohm R A, Brandt P A van den

Primary Institution: Maastricht University

Hypothesis

Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk?

Conclusion

Only b-cryptoxanthin intake appeared to be inversely associated with bladder cancer risk.

Supporting Evidence

  • The study included 120,852 subjects aged 55–69 years.
  • Data from 569 cases and 3123 subcohort members were analyzed.
  • Only b-cryptoxanthin intake was inversely associated with bladder cancer risk.

Takeaway

This study looked at whether eating certain vitamins affects the chance of getting bladder cancer, and found that only one vitamin, b-cryptoxanthin, seemed to help reduce that chance.

Methodology

The study used a food-frequency questionnaire to measure vitamin intake and followed 120,852 subjects for 6.3 years.

Participant Demographics

Subjects aged 55–69 years at baseline.

Statistical Information

P-Value

0.08 for vitamin C, <0.01 for b-cryptoxanthin

Confidence Interval

95% CI: 0.61–1.07 for vitamin C, 95% CI: 0.53–1.03 for b-cryptoxanthin

Statistical Significance

p<0.01

Digital Object Identifier (DOI)

10.1054/bjoc.2001.1968

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