Mersacidin and its Effect on Staphylococcus aureus
Author Information
Author(s): Peter Sass, Andreas Jansen, Christiane Szekat, Vera Sass, Hans-Georg Sahl, Gabriele Bierbaum
Primary Institution: Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University of Bonn
Hypothesis
Does mersacidin induce the cell wall stress response in Staphylococcus aureus?
Conclusion
Mersacidin is a strong inducer of the cell wall stress response in S. aureus at very low concentrations.
Supporting Evidence
- Mersacidin induced the cell wall stress response in S. aureus at concentrations as low as 0.15 × MIC.
- The transcription of VraDE ABC transporter genes was induced up to 1700-fold.
- Mersacidin's efficacy was not affected by increased cell wall thickness in resistant strains.
Takeaway
Mersacidin is a special type of antibiotic that helps fight bacteria by making them stressed, even when used in tiny amounts.
Methodology
Gene expression profiling using full genome microarrays and quantitative Real-Time PCR.
Limitations
The study may not account for all strains of S. aureus or other environmental factors affecting results.
Participant Demographics
Three strains of Staphylococcus aureus with varying susceptibility characteristics.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website