PHI-base – the multi-species pathogen–host interaction database in 2025
Author Information
Author(s): Urban Martin, Cuzick Alayne, Seager James, Nonavinakere Nagashree, Sahoo Jahobanta, Sahu Pallavi, Iyer Vijay Laksmi, Khamari Lokanath, Martinez Manuel Carbajo, Hammond-Kosack Kim E
Primary Institution: Rothamsted Research
Conclusion
PHI-base version 4.17 has significantly increased its gene and interaction content, providing a comprehensive resource for studying pathogen-host interactions.
Supporting Evidence
- PHI-base has been updated to version 4.17, which includes 9973 genes and 22,415 pathogen-host interactions.
- The database now supports the Frictionless Data framework for better data sharing.
- PHI-base has increased its gene content by 19% and interactions by 23% compared to the previous version.
Takeaway
PHI-base is a database that helps scientists understand how different pathogens interact with their hosts, and it has been updated to include more information about these interactions.
Methodology
The database was updated with new curation workflows and integrated with external resources to enhance data accessibility and usability.
Limitations
The database does not include viral pathogens and may have gaps in functional annotations for some proteins.
Digital Object Identifier (DOI)
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