Effects of Mild Gestational Diabetes on Baby's Hormones
Author Information
Author(s): Louise K Pirc, Julie A Owens, Caroline A Crowther, Kristyn Willson, Miles J De Blasio, Jeffrey S Robinson
Primary Institution: The University of Adelaide, Women's and Children's Hospital
Hypothesis
Maternal GDM increases cord blood concentrations of glucose, insulin and leptin, but decreases concentrations of adiponectin.
Conclusion
Treatment of women with mild GDM influences the altered fetal adipoinsular axis characteristic of mild GDM in pregnancy.
Supporting Evidence
- Babies of women with mild GDM in the Routine Care group had increased cord blood glucose concentrations.
- Treatment of mild GDM did not lower cord blood glucose to that of women without mild GDM.
- Leptin concentrations were around 22% higher in cord blood in the Routine Care group compared with the Treatment group.
Takeaway
Moms with mild diabetes during pregnancy can affect their baby's hormone levels, but treating the diabetes can help some of these issues.
Methodology
Cord blood was collected from women in the ACHOIS trial, and plasma glucose, insulin, leptin, and adiponectin concentrations were measured.
Limitations
The study did not directly assess infant fat mass.
Participant Demographics
95 women with mild GDM and 133 control women with normal OGTT.
Statistical Information
P-Value
p = 0.01 for glucose, p = 0.02 for leptin, p = 0.02 for adiponectin.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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