Evaluating Lymph Node Counts in Lung Cancer Survival
Author Information
Author(s): Huang Qiming, Chen Shai, Xiao Yuanyuan, Chen Wei, He Shancheng, Xie Baochang, Zhao Wenqi, Xu Yuhui, Luo Guiping
Primary Institution: The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University
Hypothesis
Does the count of negative and positive lymph nodes, along with the lymph node ratio, provide better prognostic information for survival in non-small cell lung cancer patients?
Conclusion
Higher counts of negative lymph nodes are associated with better survival outcomes in non-small cell lung cancer patients.
Supporting Evidence
- NLN count, NPLN, and LNR were identified as independent prognostic indicators.
- Higher NLN counts were associated with better survival outcomes.
- Lower NPLN and LNR values indicated worse outcomes.
- The NLN-based model exhibited the strongest predictive performance.
Takeaway
This study found that having more negative lymph nodes is a good sign for lung cancer patients because it means they are likely to live longer.
Methodology
Data from the SEER 17 Registry Database (2010–2019) was analyzed using Cox regression models to assess the prognostic value of lymph node counts.
Potential Biases
Missing data in the SEER database may introduce bias into the results.
Limitations
The study relies on the SEER database, which may have limitations in accuracy and completeness, lacking clinical staging data and information on comorbidities.
Participant Demographics
{"age":{"under_65":17829,"65_and_over":34961},"sex":{"male":24582,"female":28208},"race":{"white":43882,"black":4326,"other":4582}}
Statistical Information
P-Value
p<0.0001
Confidence Interval
{"NLN":"95% CI = 0.76–0.83","NPLN":"95% CI = 1.79–2.67","LNR":"95% CI = 1.34–2.01"}
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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