ESOT Guidelines for Personalized Medicine in Transplantation
Author Information
Author(s): Cillo Umberto, Jochmans Ina, Montserrat Nuria, Pengel Liset H. M., Thuraisingham Raj, Selzner Nazia, Weissenbacher Annemarie
Primary Institution: Padova University Hospital
Conclusion
This Special Issue compiles outcomes from rigorous consensus processes to provide clinical guidance in critical areas of organ transplantation.
Supporting Evidence
- Consensus guidelines recommend adopting donor-derived cell-free DNA to identify antibody-mediated rejection in patients.
- Routine monitoring of donor-specific antibodies is recommended to optimize long-term kidney graft survival.
- Standardized pre-implantation biopsy procedures for evaluating kidney grafts from expanded criteria donors are emphasized.
- Challenges in liver transplantation for patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease are discussed.
- Downstaging protocols in liver transplantation for hepatocellular carcinoma patients are strongly recommended.
- Value-based endpoints in liver transplantation are identified as important for person-centered outcomes.
- Biomarkers are limited in predicting recurrence of certain liver diseases but show promise in other areas.
- Prehabilitation strategies for transplant candidates are advocated to improve outcomes.
Takeaway
Doctors are changing how they treat patients by focusing on individual needs instead of using the same treatment for everyone. This helps make sure each patient gets the best care possible.
Methodology
The editorial discusses the establishment of a taskforce by the European Society of Organ Transplantation to create guidelines and consensus processes for personalized medicine in transplantation.
Digital Object Identifier (DOI)
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