Survivin mRNA as a Prognostic Biomarker for Oesophageal Cancer
Author Information
Author(s): Ikeguchi M, Kaibara N
Primary Institution: First Department of Surgery, Faculty of Medicine, Tottori University
Hypothesis
Is survivin mRNA expression a good prognostic biomarker for oesophageal squamous cell carcinoma?
Conclusion
Survivin mRNA expression is a reliable biomarker for identifying patients at high risk of cancer recurrence in oesophageal squamous cell carcinoma.
Supporting Evidence
- The survivin/GAPDH ratio in tumors was significantly higher than in non-cancerous tissues.
- Patients with high survivin mRNA expression had a 5-year survival rate of only 14.1%, compared to 46.8% for those with low expression.
- Survivin mRNA expression was identified as an independent risk factor for cancer recurrence.
Takeaway
This study found that measuring a specific molecule called survivin in cancer tissues can help doctors know which patients are more likely to have their cancer come back.
Methodology
Real-time reverse transcriptase polymerase chain reaction (RT–PCR) was used to analyze survivin mRNA levels in tumor and non-cancerous tissues.
Limitations
The study did not assess the impact of preoperative chemotherapy or radiation therapy on survivin expression.
Participant Demographics
The study included 57 patients, 54 men and 3 women, with a mean age of 65.2 years.
Statistical Information
P-Value
0.0003
Statistical Significance
p=0.0003
Digital Object Identifier (DOI)
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