Effects of Lactoferrin and Lactoperoxidase Tablets on Periodontitis
Author Information
Author(s): Eiju Shimizu, Tetsuo Kobayashi, Hiroyuki Wakabayashi, Koji Yamauchi, Keiji Iwatsuki, Hiromasa Yoshie
Primary Institution: Niigata University Graduate School of Medical and Dental Sciences
Hypothesis
Does oral administration of lactoferrin and lactoperoxidase-containing tablets improve periodontal conditions in chronic periodontitis patients?
Conclusion
The study found that the effect of oral administration of lactoferrin and lactoperoxidase-containing tablets on periodontal and bacteriological profiles might be weak.
Supporting Evidence
- Bovine lactoferrin levels in saliva and GCF were significantly higher in the test group.
- No significant differences were observed in clinical periodontal parameters between the two groups.
- Both groups showed a weak trend toward a decrease in levels of periodontal inflammation and destruction.
Takeaway
This study tested if special tablets could help people with gum disease, but they didn't really make a difference.
Methodology
Seventy-two individuals with chronic periodontitis were randomly assigned to take either lactoferrin and lactoperoxidase tablets or control tablets for 12 weeks, with various clinical and bacteriological assessments conducted.
Potential Biases
There may have been an attention bias affecting the perceived outcomes.
Limitations
The study may have been limited by the insufficient concentration of lactoferrin for effective antibacterial activity.
Participant Demographics
The participants included 33 males and 41 females, aged 32 to 73 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website