Antifungal Effects of Posaconazole and Voriconazole on Soft Liners
Author Information
Author(s): Muacevic Alexander, Adler John R, Sharma Madhurima, Bhatia Taniya, Sharma Rohit, Nandan Rohit
Primary Institution: Teerthanker Mahaveer Dental College and Research Centre
Hypothesis
This study aimed to evaluate and compare the antifungal activity of soft liners when combined with posaconazole and voriconazole.
Conclusion
Posaconazole in soft liners showed a significantly higher zone of growth inhibition than the other two groups.
Supporting Evidence
- Posaconazole showed a higher zone of inhibition compared to voriconazole.
- The study observed significant differences in antifungal activity over time.
- The highest zone of inhibition was recorded on day 20 for posaconazole.
Takeaway
The study tested how well two antifungal medicines work when mixed with a soft material used in dentures, finding that one medicine worked much better than the other.
Methodology
The study used three groups of five samples each, testing the antifungal activity of soft liners with and without antifungal drugs over 20 days.
Limitations
The study's findings should be combined with in vivo investigations to ascertain the clinical behavior of the antifungal drugs.
Participant Demographics
Participants were from the Department of Prosthodontics at Teerthanker Mahaveer Dental College and Research Centre, Moradabad, India.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website