Anticoagulant Treatment and Thrombosis After Pancreatic Surgery
Author Information
Author(s): Mehdi Ouaïssi, Igor Sielezneff, Nicolas Pirro, Rémi Bon Mardion, Jean Batiste Chaix, Abdelrhame Merad, Stéphane Berdah, Vincent Moutardier, Silvia Cresti, Olivier Emungania, Loundou Anderson, Christian Brunet, Bernard Sastre
Primary Institution: Hôpital Timone, Marseille, France
Hypothesis
Does postoperative anticoagulant treatment affect the thrombosis rate after portal venous resection?
Conclusion
Postoperative anticoagulation does not effectively prevent thrombosis after portal vein resection during pancreaticoduodenectomy.
Supporting Evidence
- Thrombosis rates were 0%, 41%, and 100% for types I, II, and IV resections, respectively.
- Curative anticoagulant treatment was indicated for type IV resections and some type II resections.
- Overall mortality was 11% and overall morbidity was 48%.
Takeaway
The study found that giving blood thinners after surgery didn't help stop blood clots from forming in patients who had part of their pancreas removed.
Methodology
The study analyzed 27 patients who underwent portal vein resection during pancreaticoduodenectomy, assessing the impact of anticoagulant treatment on thrombosis rates.
Potential Biases
Potential biases may arise from the non-randomized design and selection of patients.
Limitations
The study is limited by its retrospective nature and small sample size.
Participant Demographics
The mean age of participants was 66 years, with 15 males and most operated on for malignant tumors.
Statistical Information
P-Value
0.65
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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