Amebiasis in HIV-1-Infected Japanese Men: Clinical Features and Response to Therapy
Author Information
Author(s): Watanabe Koji, Gatanaga Hiroyuki, Cadiz Aleyla Escueta-de, Tanuma Junko, Nozaki Tomoyoshi, Oka Shinichi
Primary Institution: AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan
Hypothesis
What are the clinical and epidemiological features of invasive amebiasis in HIV-1 patients?
Conclusion
The treatment of uncomplicated amebiasis in HIV-1-infected individuals with metronidazole or tinidazole was highly effective, but luminal treatment did not reduce recurrence rates.
Supporting Evidence
- High fever, leukocytosis, and high CRP were associated with extraluminal amebic diseases.
- Recurrence of amebiasis was more frequent in HCV-antibody positive individuals.
- Treatment with metronidazole or tinidazole was successful in 165 out of 170 cases.
Takeaway
This study looked at men with HIV who also had amebiasis, a type of infection. It found that the usual treatments worked well, but taking extra medicine afterward didn't help stop the infection from coming back.
Methodology
The study analyzed medical records of 170 HIV-1-infected patients with invasive amebiasis and performed genotyping on 14 cases.
Potential Biases
Potential biases may arise from the retrospective nature of the study and the specific demographic of participants.
Limitations
The study was retrospective and limited to a specific population in Japan, which may not be generalizable.
Participant Demographics
All participants were male, with 96.5% identifying as men who have sex with men (MSM).
Statistical Information
P-Value
0.004
Confidence Interval
95% CI not specified
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website