Lipogenesis in Tumor and Host Tissues in Mice with Colon Adenocarcinomas
Author Information
Author(s): H.D. Mulligan, M.J. Tisdale
Primary Institution: CRC Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University
Hypothesis
Does the presence of colon adenocarcinomas affect lipogenesis in host tissues?
Conclusion
The MAC16 tumor induces significant weight loss in mice, associated with reduced body fat, while both MAC16 and MAC13 tumors increase lipogenesis in host tissues.
Supporting Evidence
- Animals with the MAC16 tumor lost weight despite similar food intake compared to controls.
- Both MAC16 and MAC13 tumors increased lipogenesis in host tissues.
- Weight loss in MAC16 tumor-bearing mice was linked to a reduction in body fat.
Takeaway
Mice with a specific type of colon cancer lose weight because their bodies are using fat for energy, even though they eat the same amount of food as healthy mice.
Methodology
Mice were implanted with tumor fragments and their food intake, weight loss, and lipogenesis rates were measured.
Limitations
The study only examined two types of tumors and their effects on a specific mouse strain.
Participant Demographics
Male NMRI mice were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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