Understanding Radiologically Isolated Syndrome in Multiple Sclerosis
Author Information
Author(s): De Stefano Nicola, Stromillo Maria Laura, Rossi Francesca, Battaglini Marco, Giorgio Antonio, Portaccio Emilio, Hakiki Bahia, Malentacchi Gianmichele, Gasperini Claudio, Santangelo Mario, Bartolozzi Maria Letizia, Sormani Maria Pia, Federico Antonio, Amato Maria Pia
Primary Institution: Department of Neurological and Behavioral Sciences, University of Siena, Italy
Hypothesis
To improve the characterization of asymptomatic subjects with brain MRI abnormalities suggestive of multiple sclerosis.
Conclusion
Macroscopic brain damage was similar in RIS and RRMS, but subtle tissue damage was milder in RIS, suggesting a lack of clinical manifestations.
Supporting Evidence
- Lesional-MTr values were lower in RRMS than in RIS.
- Brain volumes were similarly lower in RRMS and RIS than in healthy controls.
- 13 out of 19 RIS subjects had a high probability of being classified as RRMS.
Takeaway
Some people have brain changes that look like multiple sclerosis but don't have any symptoms. This study helps us understand those changes better.
Methodology
Quantitative MRI metrics were assessed in 19 RIS subjects, 20 RRMS patients, and 20 healthy controls.
Potential Biases
Potential sampling bias as all subjects were contacted by the same neurologist.
Limitations
The study's findings may not apply to all RIS subjects due to the small sample size.
Participant Demographics
19 asymptomatic subjects (14 females, 5 males, mean age 37 years).
Statistical Information
P-Value
p=0.048
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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