Correlation of MMSE and Tau Results in Alzheimer's Patients
Author Information
Author(s): Sunil Surya, Nair Malini, Huang Rui, Obando Viviana, Ferreira Kyra, Glynn Jennifer, Nair Anil
Primary Institution: Boston Neuropsychiatry
Hypothesis
Does the correlation of blood or PET tau positivity relate to MMSE test scores?
Conclusion
The study found that tau results trended negatively with MMSE scores, suggesting a possible ceiling effect in mildly impaired subjects.
Supporting Evidence
- 45 positive and 10 negative tau results were disclosed.
- Mean MMSE score was 21.35±7.36.
- A cut point of 28 for MMSE estimated tau deposition in the brain.
Takeaway
The study looked at how well a memory test score relates to tau levels in the blood or brain scans of Alzheimer's patients.
Methodology
Retrospective observational chart review of patients attending a memory clinic, analyzing MMSE scores and tau results.
Limitations
The study was small and only included mildly impaired subjects.
Participant Demographics
58.2% female, 82.7% white, mean age 70.12 years.
Statistical Information
P-Value
0.07
Confidence Interval
95%CI 0.48 to 0.90
Statistical Significance
p=0.07
Digital Object Identifier (DOI)
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