Risk factors for bloodstream infection in COVID-19 patients in intensive care units: a systematic review and meta-analysis
2025

Risk Factors for Bloodstream Infection in COVID-19 ICU Patients

Sample size: 25939 publication 10 minutes Evidence: high

Author Information

Author(s): Jun Wang, Ting Jiang

Primary Institution: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Hypothesis

What are the risk factors for bloodstream infection in COVID-19 patients in intensive care units?

Conclusion

Ten risk factors for bloodstream infection in COVID-19 patients in ICUs were identified, which can help in developing predictive models for better patient management.

Supporting Evidence

  • Men were found to have a 28% higher risk of bloodstream infection.
  • Diabetes increased the risk of bloodstream infection by 34%.
  • Tracheal intubation was associated with a nearly 9-fold increase in risk.
  • Mechanical ventilation increased the risk of bloodstream infection by 22 times.
  • Central venous cannulation was linked to a 9-fold increase in risk.
  • Longer ICU stays correlated with a higher risk of bloodstream infection.

Takeaway

This study found that certain factors, like being male and having diabetes, can make COVID-19 patients in the ICU more likely to get infections in their blood.

Methodology

A systematic review and meta-analysis were conducted, analyzing data from 55 studies to identify risk factors for bloodstream infections.

Potential Biases

Potential biases due to differences in study methodologies and patient populations.

Limitations

The studies included varied in design and population, which may affect the generalizability of the findings.

Participant Demographics

Patients ranged in age from 18 to 94 years, with a majority being male.

Statistical Information

P-Value

0.006

Confidence Interval

95% CI: 1.10–1.50

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/s12879-024-10420-1

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