HER-2 Overexpression in Tunisian Breast Cancer
Author Information
Author(s): Ayadi Lobna, Khabir Abdelmajid, Amouri Habib, Karray Sondes, Dammak Abdallah, Guermazi Mohamed, Boudawara Tahya
Primary Institution: Habib Bourguiba University Hospital, Sfax, Tunisia
Hypothesis
The study aims to evaluate the expression of HER-2, estrogen receptor (ER), and progesterone receptors (PR) in breast carcinoma and compare it with other prognostic parameters.
Conclusion
HER-2 over-expression was observed in 18.1% of Tunisian breast carcinoma cases, indicating an aggressive form of the disease.
Supporting Evidence
- HER-2 was over-expressed (3+) in 18.1% of the cases.
- The expression of HER-2 was inversely related to ER expression (p = 0.00).
- A negative correlation was noted between ER and PR expression and SBR grade (p = 0.000).
Takeaway
This study found that a small part of breast cancer cases in Tunisia have a specific protein that can make the cancer more aggressive.
Methodology
A retrospective study using immunohistochemistry to evaluate HER-2, ER, and PR expression in breast carcinoma cases.
Limitations
The study was limited by the relatively small number of non-ductal subtypes.
Participant Demographics
Patients' ages ranged from 22 to 89 years, with a mean age of 51.5 years; 51.6% were below 50 years old.
Statistical Information
P-Value
p = 0.000 for ER and HER-2 correlation
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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