Deletions at 14q in malignant mesothelioma detected by microsatellite marker analysis
1999
Genetic Deletions in Malignant Mesothelioma
Sample size: 18
publication
Evidence: moderate
Author Information
Author(s): Björkqvist A-M, Wolf M, Nordling S, Tammilehto L, Knuuttila A, Kere J, Mattson K, Knuutila S
Primary Institution: University of Helsinki
Hypothesis
Are deletions at chromosome 14q common in malignant mesothelioma?
Conclusion
Genomic deletions at 14q are more common in malignant mesothelioma than previously reported.
Supporting Evidence
- Loss of heterozygosity or allelic imbalance was detected in 56% of the tumors.
- Partial deletions were more common than complete loss of markers.
- The most frequent deletions were found at specific markers on chromosome 14q.
Takeaway
Researchers looked at tumors from people with a type of cancer called mesothelioma and found that a specific part of their DNA was often missing.
Methodology
High-resolution deletion mapping analysis of 23 microsatellite markers was performed on 18 primary mesothelioma tumors.
Limitations
The number of tumors analyzed was small and the deletion pattern was complex.
Digital Object Identifier (DOI)
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