Ethyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
2011
Study of a New Drug Intermediate for Epilepsy Treatment
publication
Evidence: moderate
Author Information
Author(s): Jia Jing, Lu Dingqiang
Primary Institution: Nanjing University of Technology
Hypothesis
The title compound is a key intermediate in the synthesis of rufinamide, a new anti-epilepsy drug.
Conclusion
The crystal structure of the title compound shows that it forms one-dimensional chains linked by weak hydrogen bonds.
Supporting Evidence
- The dihedral angle between the triazole and phenyl rings is 73.74°.
- The discrete molecules are linked through weak hydrogen bonds.
- The compound was synthesized with a yield of 86.3%.
Takeaway
This study looks at a new chemical compound that helps make a medicine for epilepsy. The compound has a special structure that helps it connect with other molecules.
Methodology
The compound was synthesized and its crystal structure was analyzed using X-ray diffraction.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website