Nutrition and Tumor Growth in Mice
Author Information
Author(s): T. Westin, B. Soussi, J.-P. Idström, P. Lindner, S. Edström, E. Lyden, B. Gustavsson, L. Hafström, K. Lundholm
Primary Institution: University of Goteborg and Linkoping University, Sweden
Hypothesis
Does food intake modulate experimental tumor growth by altering the energy state and blood flow of the tumor?
Conclusion
The study found that undernutrition slows tumor growth by decreasing the tumor's energy state and blood flow.
Supporting Evidence
- Starvation reduced tumor growth and energy levels in mice.
- Refeeding after starvation restored tumor energy levels and growth.
- Inhibition of ODC activity decreased DNA synthesis in tumors.
Takeaway
When mice with tumors don't eat, their tumors grow slower because they have less energy. But when they eat again, the tumors can start growing faster.
Methodology
Inbred mice with tumors were starved and then refed, while measuring tumor energy levels and DNA synthesis.
Limitations
The study was conducted on a specific mouse strain and may not generalize to all types of tumors or species.
Participant Demographics
Sex matched male and female C57BL/6J mice, aged 3 months.
Statistical Information
P-Value
p<0.05
Confidence Interval
95%
Statistical Significance
p<0.05
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