Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats
2008
Danaparoid Sodium Helps Organ Function in Sepsis
Sample size: 64
publication
Evidence: moderate
Author Information
Author(s): Iba Toshiaki, Miyasho Taku
Primary Institution: Juntendo University
Hypothesis
Is danaparoid sodium effective for the treatment of organ dysfunction in sepsis?
Conclusion
Danaparoid sodium preserves organ function in rats challenged with lipopolysaccharide.
Supporting Evidence
- Danaparoid sodium significantly suppressed the elevation of organ damage markers in the treated group.
- Proinflammatory cytokines were significantly lower in the danaparoid sodium group compared to the control group.
- Coagulation markers were better maintained in the danaparoid sodium group.
Takeaway
Danaparoid sodium is like a medicine that helps sick rats feel better when they have a serious infection.
Methodology
Sixty-four Wistar rats were injected with lipopolysaccharide and divided into two groups: one received danaparoid sodium and the other saline, with various blood samples taken for analysis.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Ten-week-old Wistar rats
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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