A single point-mutation within the melanophilin gene causes the lavender plumage colour dilution phenotype in the chicken
2008
Mutation in Melanophilin Causes Lavender Plumage in Chickens
Sample size: 159
publication
Evidence: high
Author Information
Author(s): Vaez Mohsen, Follett Sarah A, Bed'hom Bertrand, Gourichon David, Tixier-Boichard Michèle, Burke Terry
Primary Institution: Department of Animal and Plant Sciences, University of Sheffield
Hypothesis
The melanophilin gene may underlie the lavender plumage phenotype in chickens.
Conclusion
This study identifies a mutation in the MLPH gene as the cause of the lavender plumage phenotype in chickens.
Supporting Evidence
- The mutation in the MLPH gene results in an amino acid change associated with similar phenotypes in other species.
- The study confirmed the association of the C103T SNP with the lavender phenotype in a pedigree analysis.
- MLPH is located on chicken chromosome 7 and consists of 17 exons.
Takeaway
Chickens with lavender feathers have a tiny change in their genes that makes their colors lighter.
Methodology
The study used a candidate-gene approach and comparative sequence analysis to identify mutations in the MLPH gene.
Participant Demographics
The study involved 159 chickens from various breeds.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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