Repurposing Sodium-Glucose Co-Transporter-2 Inhibitors for Gerotherapy
2024
Repurposing SGLT2 Inhibitors for Aging Therapy
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Solis-Herrera Carolina, Venna Venugopal, Lee Juneyoung
Primary Institution: University of Texas, San Antonio
Hypothesis
Can SGLT2 inhibitors improve healthspan and lifespan in older adults?
Conclusion
SGLT2 inhibitors may help reduce aging-related issues and improve health in older adults with prediabetes.
Supporting Evidence
- SGLT2 inhibitors can reduce HbA1c and improve insulin sensitivity.
- They provide significant cardio-renal benefits.
- SGLT2 inhibitors may shift metabolism towards ketone bodies.
- Preclinical studies show anti-inflammatory and anti-oxidative properties.
Takeaway
SGLT2 inhibitors are medicines that might help older people live healthier and longer by changing how their bodies use energy.
Methodology
Treatment with an SGLT2 inhibitor for 12 weeks in older, obese subjects with prediabetes.
Limitations
Clinical research in this area is still limited.
Participant Demographics
Older, obese subjects with prediabetes.
Digital Object Identifier (DOI)
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