Cognitive and Emotional Changes Linked to Brain Inflammation in Mice with Metabolic Syndrome
Author Information
Author(s): Dinel Anne-Laure, André Caroline, Aubert Agnès, Ferreira Guillaume, Layé Sophie, Castanon Nathalie
Primary Institution: Nutrition et Neurobiologie Intégrée, INRA UMR 1286, Bordeaux, France
Hypothesis
The behavioral deficits of db/db mice would be specifically associated with activation of cytokine pathways in the hippocampus.
Conclusion
Increased anxiety-like behaviors and impaired spatial memory in db/db mice are linked to inflammation in the hippocampus.
Supporting Evidence
- db/db mice displayed increased anxiety-like behaviors in the open-field and elevated plus-maze.
- db/db mice showed impaired spatial recognition memory but unaltered object recognition memory.
- Increased inflammatory cytokines were found in the hippocampus of db/db mice.
Takeaway
Mice with metabolic syndrome showed more anxiety and memory problems because of inflammation in their brains.
Methodology
The study used a mouse model of metabolic syndrome to assess emotional behaviors and memory performances alongside inflammatory cytokine levels.
Limitations
The study is correlative and conducted in mice, which may not fully represent human conditions.
Participant Demographics
Male db/db and db/+ mice aged 8 to 10 weeks.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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